Thrombopoietin: Biology and Clinical Applications
نویسندگان
چکیده
منابع مشابه
Thrombopoietin: Biology and Clinical Applications.
Thrombopoietin (also called c-Mpl ligand, megakaryocyte growth and development factor, megapoietin) has recently been purified and cloned. This molecule is indeed the long-sought-after hematopoietic factor that controls platelet production. Thrombopoietin levels increase within 24 h after the onset of thrombocytopenia and are inversely and exponentially proportional to the platelet count. Injec...
متن کاملThrombopoietin: biology and potential clinical applications.
After an almost 40-year search for a primary regulatory of platelet production, thrombopoietin has recently been purified and cloned. Thrombopoietin regulates all stages in the production of platelets by promoting both the proliferation of megakaryocyte progenitors and their maturation into platelet-producing megakaryocytes. In preclinical studies in normal mice and non-human primates, administ...
متن کاملCommentary (Schiffer)—Thrombopoietin: Biology and Potential Clinical Applications
Early trials of thrombopoietins have shown: (1) a dose-dependent rise in platelet count beginning a few days after administration and peaking at 10 to 14 days, without changes in red blood cell or neutrophil counts; (2) the production of morphologically and functionally normal platelets; (3) mobilization of hematopoietic colony-forming units into the peripheral blood; (4) attenuation of the mil...
متن کاملCommentary (Schiffer)—Thrombopoietin: Biology and Potential Clinical Applications
Early trials of thrombopoietins have shown: (1) a dose-dependent rise in platelet count beginning a few days after administration and peaking at 10 to 14 days, without changes in red blood cell or neutrophil counts; (2) the production of morphologically and functionally normal platelets; (3) mobilization of hematopoietic colony-forming units into the peripheral blood; (4) attenuation of the mil...
متن کاملRecombinant human thrombopoietin: basic biology and evaluation of clinical studies.
Thrombocytopenia is a common medical problem for which the main treatment is platelet transfusion. Given the increasing use of platelets and the declining donor population, identification of a safe and effective platelet growth factor could improve the management of thrombocytopenia. Thrombopoietin (TPO), the c-Mpl ligand, is the primary physiologic regulator of megakaryocyte and platelet devel...
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ژورنال
عنوان ژورنال: The Oncologist
سال: 1996
ISSN: 1083-7159,1549-490X
DOI: 10.1634/theoncologist.1-1-98